CD8-depleted non-engrafting HLA-mismatched unrelated donor lymphocytes

{
  "id": "MLC-T-ONC-012425",
  "term": "CD8-depleted non-engrafting HLA-mismatched unrelated donor lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic lymphocytes from an HLA-mismatched donor that have been selectively depleted of CD8+ T cells, with potential T-cell reconstitution purposes. Upon infusion, the donor-derived CD8+-depleted lymphocytes may increase the levels of CD4+ T cells (Teffs) and promote T-cell reconstitution. The infusion of donor lymphocytes depleted of CD8 T cells may reduce the risk of inducing graft-versus-host disease (GVHD) compared to the infusion of non-CD8-depleted T cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd8-depleted-non-engrafting-hla-mismatched-unrelated-donor-lymphocytes/"
}