CD45RA-depleted donor T lymphocytes

{
  "id": "MLC-T-ONC-012411",
  "term": "CD45RA-depleted donor T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of donor lymphocytes that have been depleted of CD45RA-positive cells, that can potentially be used for immune reconstitution purposes. CD45RA depletion results in a cellular product that contains a high amount of memory T cells (Tm). Upon infusion of the allogeneic CD45RA-depleted T lymphocytes after a hematopoietic cell transplantation (HCT), these cells provide Tm recovery and are able to prevent viral infections. The depletion of the CD45RA-positive cells reduces the risk of graft-versus-host disease (GvHD) upon infusion. CD45RA is expressed on naive T cells, whereas Tm cells are CD45RA-negative. Naive T-cells have the potential to induce GvHD.",
  "synonyms": [
    "donor CD45RA-depleted (memory) T cells",
    "CD45RA-depleted allogeneic T cells",
    "CD45RA-depleted donor T cells",
    "CD45RA-depleted allogeneic T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd45ra-depleted-donor-t-lymphocytes/"
}