Rivogenlecleucel

{
  "id": "MLC-T-ONC-016563",
  "term": "Rivogenlecleucel",
  "field": "Oncology and biomedicine",
  "definition": "Allogeneic, T-lymphocytes with potential immune reconstitution activity. Donor T-lymphocytes are transduced with a retroviral vector (BPZ-1001) encoding the inducible suicide gene caspase 9 (iCasp9) and linked to a drug binding domain. Donor T-cell therapy may help control transplant-related infections following allogeneic hematopoietic stem cell transplantation. However, the addition of donor T-cells can lead to graft-versus-host disease (GVHD). In the event that GVHD begins to develop, the chemical homodimerizer AP1903 can be administered, which binds to the drug binding domain and induces caspase 9 expression. This activates apoptosis in the T-cells causing GVHD.",
  "synonyms": [
    "allogeneic T lymphocytes BPX-501"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/rivogenlecleucel/"
}