anti-mesothelin iCasp9M28z CAR-transduced autologous T lymphocytes

{
  "id": "MLC-T-ONC-010887",
  "term": "anti-mesothelin iCasp9M28z CAR-transduced autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Genetically modified, autologous T lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for mesothelin linked to the signaling domains for the co-stimulatory molecules CD28 and CD3 zeta, as well as the suicide gene inducible caspase 9 (iCasp9 or iC9), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, anti-mesothelin iCasp9M28z CAR-transduced autologous T lymphocytes specifically target and kill mesothelin-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, a dimerizing agent can be administered, which binds to the FKBP12-F36V drug-binding domain and activates caspase 9, resulting in the apoptosis of the administered T cells. Mesothelin, a tumor-associated antigen, is overexpressed in a variety of cancer cell types.",
  "synonyms": [
    "iCasp9M28z T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-mesothelin-icasp9m28z-car-transduced-autologous-t-lymphocytes/"
}