allogeneic CD34+-enriched and CD45RA-depleted PBSCs

{
  "id": "MLC-T-ONC-009854",
  "term": "allogeneic CD34+-enriched and CD45RA-depleted PBSCs",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of donor-derived peripheral blood stem cells (PBSCs) that have been enriched with CD34-positive stem cells and have been depleted of CD45RA-positive cells, that can potentially be used for immune reconstitution purposes. CD45RA depletion results in a cellular product that contains a high amount of memory T cells (Tm). Upon infusion of the allogeneic CD34+-enriched and CD45RA-depleted PBSCs after a hematopoietic cell transplantation (HCT), these cells provide Tm recovery and are able to prevent viral infections. The depletion of the CD45RA-positive cells reduces the risk of graft-versus-host disease (GvHD) upon infusion. CD45RA is expressed on naive T cells (Tn), whereas Tm cells are CD45RA-negative. Tn cells have the potential to induce more severe GvHD than Tm cells.",
  "synonyms": [
    "allogeneic Tn-depleted CD34-preserved PBSCs",
    "allogeneic TnD- CD34+ PBSCs",
    "donor-derived Tn cell-depleted CD34-enriched PBSCs",
    "naive T-cell-depleted CD34+ allogeneic peripheral blood stem cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-cd34-plus-enriched-and-cd45ra-depleted-pbscs/"
}