donor TCR alpha/beta/CD19-depleted mononuclear cell-enriched activated natural killer cells

{
  "id": "MLC-T-ONC-013142",
  "term": "donor TCR alpha/beta/CD19-depleted mononuclear cell-enriched activated natural killer cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of donor-derived, haploidentical, cytokine-activated natural killer (NK) cells enriched with mononuclear cells from haploidentical donor that have been depleted of T-cell receptor (TCR) alpha and beta (TCRa/b+) as well as CD19-positive (CD19+) cells, that may potentially be used for immune reconstitution purposes. Upon administration, the donor TCR alpha/beta/CD19-depleted mononuclear cell-enriched activated NK cells may enhance immune reconstitution. The depletion of alpha/beta T cells, which are implicated in the adaptive immune response that mediates graft-versus-host disease (GvHD), may promote rapid and sustained engraftment, immune reconstitution, and may prevent or reduce the development of GvHD. The depletion of CD19+ B cells may reduce the risk of Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders.",
  "synonyms": [
    "donor TCR alpha/beta/CD19-depleted mononuclear cell-enriched activated NK cells",
    "TCR alphabeta/CD19-depleted donor enriched activated natural killer cells",
    "TCR alphabeta/CD19-depleted DEA-NK cells",
    "allogeneic TCR alpha/beta/CD19-depleted mononuclear cell-enriched activated NK cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/donor-tcr-alpha-beta-cd19-depleted-mononuclear-cell-enriched-activated-natural/"
}