Donor regulatory T lymphocytes

{
  "id": "MLC-T-ONC-013141",
  "term": "Donor regulatory T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Donor-derived regulatory T-cells (Tregs), with potential immunomodulating activity. Tregs are a subset of CD4+ T cells that express high levels of CD25 (interleukin 2 receptor) and the transcription factor Foxp3. The donor CD4+CD25+ Tregs modulate immune responses and may induce tolerance to allogeneic organ transplants, such as hematopoietic stem cell transplants (HSCTs), thereby preventing graft-versus-host disease (GVHD).",
  "synonyms": [
    "donor CD4+CD25+FoxP3+ T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/donor-regulatory-t-lymphocytes/"
}