CD4+ CD25+ regulatory T cells

{
  "id": "MLC-T-ONC-012405",
  "term": "CD4+ CD25+ regulatory T cells",
  "field": "Oncology and biomedicine",
  "definition": "Regulatory T cells that express CD4 and CD25 (interleukin 2 receptor) antigens, with immunomodulating activity. CD4+CD25+ T regulatory cells (Tregs), a subset of CD4+ T cells expressing high levels of CD25 and the transcription factor Foxp3, are essential in maintaining immunologic homeostasis, preventing autoimmunity by suppressing self-reactive T cells; CD4+CD25+ Tregs may induce tolerance to allogeneic organ transplants such as hematopoetic stem cell transplants (HSCTs).",
  "synonyms": [
    "CD4+ CD25+ FOXP3+ regulatory T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd4-plus-cd25-plus-regulatory-t-cells/"
}