autologous anti-BCMA-CAR-expressing CD4+/CD8+ T lymphocytes FCARH143

{
  "id": "MLC-T-ONC-011344",
  "term": "autologous anti-BCMA-CAR-expressing CD4+/CD8+ T lymphocytes FCARH143",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of ex vivo expanded autologous CD8+ and CD4+ T cells that have been genetically modified to express a chimeric antigen receptor (CAR) specific for human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-expressing CD4+/CD8+ T lymphocytes FCARH143 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells.",
  "synonyms": [
    "BCMA-specific CAR-expressing CD4+/CD8+ T lymphocytes",
    "autologous anti-BCMA-CAR CD4+/CD8+ cells",
    "BCMA CAR-CD4+/CD8+ T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-bcma-car-expressing-cd4-plus-cd8-plus-t-lymphocytes-fcarh143/"
}