autologous anti-BCMA CD8+ CAR T cells Descartes-11

{
  "id": "MLC-T-ONC-011337",
  "term": "autologous anti-BCMA CD8+ CAR T cells Descartes-11",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous CD8-positive T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA CD8+ CAR T cells Descartes-11 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells.",
  "synonyms": [
    "autologous CD8+ T cells expressing anti-BCMA CAR Descartes-11"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-bcma-cd8-plus-car-t-cells-descartes-11/"
}