Autologous Anti-BCMA CAR T-cells IM21

{
  "id": "MLC-T-ONC-011335",
  "term": "Autologous Anti-BCMA CAR T-cells IM21",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector (LV) expressing a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and containing, as of yet undisclosed costimulatory signaling domains, with potential antineoplastic activity. Upon administration, the autologous anti-BCMA CAR T-cells IM21 recognize and induce selective toxicity against BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells.",
  "synonyms": [
    "IM21 CAR-T cells",
    "autologous BCMA-specific CAR T cells IM21",
    "IM21 CAR T cells",
    "Autologous BCMA-specific CAR T-cells IM21",
    "IM21 CAR T-cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-bcma-car-t-cells-im21/"
}