autologous mRNA-transfected anti-BCMA-CAR T lymphocytes SYS6020

{
  "id": "MLC-T-ONC-011704",
  "term": "autologous mRNA-transfected anti-BCMA-CAR T lymphocytes SYS6020",
  "field": "Oncology and biomedicine",
  "definition": "A preparation consisting of autologous T lymphocytes that have been transfected with lipid nanoparticle (LNP)-mRNA encoding for a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and containing as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous mRNA-transfected anti-BCMA-CAR T lymphocytes SYS6020 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells.",
  "synonyms": [
    "autologous BCMA-targeted CAR T cells SYS6020",
    "autologous mRNA-lipid nanoparticles-based anti-BCMA CAR T cells SYS6020",
    "autologous mRNA-LNP-based anti-BCMA CAR-T cells SYS6020"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-mrna-transfected-anti-bcma-car-t-lymphocytes-sys6020/"
}