autologous anti-BCMA-CAR-mRNA-transfected CD8+ T lymphocytes

{
  "id": "MLC-T-ONC-011346",
  "term": "autologous anti-BCMA-CAR-mRNA-transfected CD8+ T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous CD8-positive T lymphocytes that have been genetically modified via transient mRNA transfection to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-mRNA transfected CD8+ T lymphocytes specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells.",
  "synonyms": [
    "autologous anti-BCMA-CAR-mRNA-transfected CD8+ T cells",
    "autologous anti-BCMA-CAR-mRNA-transfected CD8-positive T cells",
    "anti-BCMA-CAR-mRNA-transfected autologous CD8+ T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-bcma-car-mrna-transfected-cd8-plus-t-lymphocytes/"
}