Autologous anti-BCMA-CAR-TCRz/4-1BB-expressing T lymphocytes CART-BCMA

{
  "id": "MLC-T-ONC-011347",
  "term": "Autologous anti-BCMA-CAR-TCRz/4-1BB-expressing T lymphocytes CART-BCMA",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been ex vivo transduced with a genetically-engineered lentiviral vector (LV) expressing a chimeric antigen receptor (CAR) containing an extracellular human single chain variable fragment (scFv) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) fused to an intracellular tandem signaling domain comprised of the co-stimulatory domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3z), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing T lymphocytes specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells.",
  "abbreviation": "CART-BCMA",
  "synonyms": [
    "autologous BCMA 4-1BBz CAR T cells CART-BCMA",
    "autologous BCMA-specific CAR-TCRz/4-1BB-expressing T lymphocytes CART-BCMA",
    "CART-BCMA cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-bcma-car-tcrz-4-1bb-expressing-t-lymphocytes-cart-bcma/"
}