autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing memory T lymphocytes bb21217

{
  "id": "MLC-T-ONC-011340",
  "term": "autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing memory T lymphocytes bb21217",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous memory T lymphocytes transduced, ex vivo, with a lentiviral vector expressing a chimeric antigen receptor (CAR) containing an anti-B-cell maturation antigen (BCMA) single chain variable fragment (scFv) fused to the signaling domain of 4-1BB (CD137) and a CD3-zeta T-cell activation domain, with potential immunostimulating and antineoplastic activities. Upon intravenous administration back into the patient, the autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing memory T lymphocytes bb21217 are directed to, and induce selective toxicity in, BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma survival. BCMA is overexpressed on malignant plasma cells.",
  "synonyms": [
    "autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing memory T cells bb21217"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-bcma-car-4-1bb-cd3zeta-expressing-memory-t-lymphocytes-bb21217/"
}