Equecabtagene autoleucel

{
  "id": "MLC-T-ONC-013400",
  "term": "Equecabtagene autoleucel",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) with a fully human single chain variable fragment (scFv) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, equecabtagene autoleucel specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells, and plays a key role in plasma cell proliferation and survival.",
  "synonyms": [
    "autologous anti-BCMA CAR-transduced T cells CT103A",
    "autologous anti-BCMA CAR T cells CT103A",
    "autologous anti-BCMA CAR-T cells CT103A"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/equecabtagene-autoleucel/"
}