anti-BCMA CAR-NK cells

{
  "id": "MLC-T-ONC-010160",
  "term": "anti-BCMA CAR-NK cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of umbilical cord blood (CB)-derived natural killer cells (NKs) expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-BCMA CAR-NK cells recognize, bind to and induce selective cytotoxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival.",
  "synonyms": [
    "anti-BCMA CAR-natural killer cells",
    "anti-BCMA CAR-NKs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-bcma-car-nk-cells/"
}