autologous anti-BCMA-CAR-expressing stem memory T cells P-BCMA-101

{
  "id": "MLC-T-ONC-011345",
  "term": "autologous anti-BCMA-CAR-expressing stem memory T cells P-BCMA-101",
  "field": "Oncology and biomedicine",
  "definition": "A preparation consisting of autologous T cells that are enriched to be primarily stem memory T cells (Tscm) and are transfected by electroporation with a proprietary transposon-based DNA plasmid vector (PiggyBac) containing an undisclosed selection gene and encoding both an unidentified human-derived safety switch and a chimeric antigen receptor (CAR) based on a proprietary non-immunoglobulin scaffold molecule Centyrin (CARTyrin), which specifically recognizes human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-expressing Tscm P-BCMA-101 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. Use of CARTyrin may elicit less immunotoxicity than agents based on antibody-derived single chain variable fragments (scFv), and this agent may exhibit increased persistence and decreased exhaustion for the administered T cells. If significant side effects occur, the safety switch mechanism can induce the rapid attenuation or elimination of P-BCMA-101. BCMA, a tumor-specific antigen and a member of the tumor necrosis factor receptor superfamily (TNFRSF) that binds to both a proliferation-inducing ligand (APRIL; TNFSF13) and B-cell activating factor (BAFF; TNFSF13B), plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells.",
  "synonyms": [
    "autologous P-BCMA-101 CAR-T cells",
    "autologous P-BCMA-101 CARTyrin-T cells",
    "autologous anti-BCMA centyrin-based chimeric antigen receptor-expressing Tscm"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-bcma-car-expressing-stem-memory-t-cells-p-bcma-101/"
}