autologous BCMA-targeted CAR T cells LCAR-B4822M

{
  "id": "MLC-T-ONC-011514",
  "term": "autologous BCMA-targeted CAR T cells LCAR-B4822M",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous peripheral blood T lymphocytes (PBTLs) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous BCMA-targeted CAR T cells LCAR-B4822M specifically recognize and kill BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma cell survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells.",
  "synonyms": [
    "LCAR-B4822M CAR T lymphocytes",
    "autologous LCAR-B4822M CAR T cells",
    "LCAR-B4822M-02 cells",
    "BCMA-specific CAR-expressing T lymphocytes LCAR-B4822M"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-bcma-targeted-car-t-cells-lcar-b4822m/"
}