BCMA-specific universal CAR-expressing T lymphocytes LCAR-BCX

{
  "id": "MLC-T-ONC-011914",
  "term": "BCMA-specific universal CAR-expressing T lymphocytes LCAR-BCX",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of universal T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, BCMA-specific universal CAR-expressing T lymphocytes LCAR-BCX are directed to cells expressing BCMA and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is overexpressed on malignant plasma cells.",
  "synonyms": [
    "BCMA-targeted universal LCAR-BCX cells",
    "LCAR-BCX cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bcma-specific-universal-car-expressing-t-lymphocytes-lcar-bcx/"
}