inducible CD4+CD25+ regulatory T cells

{
  "id": "MLC-T-ONC-014447",
  "term": "inducible CD4+CD25+ regulatory T cells",
  "field": "Oncology and biomedicine",
  "definition": "Inducible regulatory T-lymphocytes that express CD4, CD25 (the alpha chain of the interleukin 2 receptor) and forkhead box P3 (FOXP3), with potential immunomodulating activity. Inducible CD4+CD25+ T regulatory cells (iTregs) are a subset of CD4+ T lymphocytes that are induced from CD25- precursors in peripheral lymphoid organs with interleukin-2 and transforming growth factor-beta. These regulatory T cells are essential in maintaining immunologic homeostasis. They may also prevent autoimmunity by suppressing self-reactive T cells, and may induce tolerance to allogeneic organ transplants such as in hematopoietic stem cell transplants.",
  "synonyms": [
    "iTregs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/inducible-cd4-plus-cd25-plus-regulatory-t-cells/"
}