allogeneic CMV antigen-specific CD4+/CD8+ T lymphocytes

{
  "id": "MLC-T-ONC-009862",
  "term": "allogeneic CMV antigen-specific CD4+/CD8+ T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A population of allogeneic T lymphocytes specifically reactive to cytomegalovirus (CMV) with potential antiviral activity. Allogeneic CMV antigen-specific T cells are prepared via ex vivo stimulation of donor-derived peripheral blood mononuclear cells (PBMCs) with major cytomegalovirus structural protein, pp65 (ppUL83). T cells that secrete interferon (IFN)-gamma in response to pp65 antigen exposure are selected and expanded for administration. Administration of the CMV antigen-specific CD4+ and CD8+T lymphocytes into hematopoietic stem cell transplant (HSCT) or immunocompromised patients infected with CMV may potentially reconstitute virus-specific responses, thereby controlling CMV infections",
  "synonyms": [
    "allogeneic cytomegalovirus-specific CD4+ and CD8+ T lymphocytes",
    "allogeneic cytomegalovirus-specific CD4+ and CD8+ T cells",
    "allogeneic CMV-specific antigen-selected T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-cmv-antigen-specific-cd4-plus-cd8-plus-t-lymphocytes/"
}