allogeneic HPV-specific CD4+ T lymphocytes

{
  "id": "MLC-T-ONC-009902",
  "term": "allogeneic HPV-specific CD4+ T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic T lymphocytes, collected from a haploidentical donor of the patient after vaccination with human papillomavirus (HPV) vaccine series, and depleted of CD8+ lymphocytes, with potential antiviral and antineoplastic activities. Upon administration, allogeneic HPV-specific CD4+ T lymphocytes may induce selective toxicity in HPV-positive cancer cells and other HPV-infected cells. HPV is associated with various cancer cell types. The depletion of CD8+ lymphocytes from the donor cell preparation may lower the risk of graft-versus-host disease (GvHD).",
  "synonyms": [
    "allogeneic HPV-specific CD4+ T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-hpv-specific-cd4-plus-t-lymphocytes/"
}