allogeneic HLA A2/4-1BB ligand-expressing melanoma vaccine

{
  "id": "MLC-T-ONC-009901",
  "term": "allogeneic HLA A2/4-1BB ligand-expressing melanoma vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An allogeneic melanoma cell vaccine derived from a cell line with high expression of melanoma associated antigens and genetically modified to express both HLA-A2 and 4-1BB ligand, with potential immunostimulating and antineoplastic activities. Upon administration, the 4-1BB ligand of the allogeneic HLA-A2/4-1BB ligand-expressing melanoma vaccine binds to 4-1BB on activated T-lymphocytes, which induces a strong immune response against HLA-A2 positive melanoma cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-hla-a2-4-1bb-ligand-expressing-melanoma-vaccine/"
}