Allogeneic CD25/Treg-depleted donor lymphocytes

{
  "id": "MLC-T-ONC-009850",
  "term": "Allogeneic CD25/Treg-depleted donor lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic peripheral blood mononuclear cells (PBMCs) derived from an 8/8 HLA-matched donor that have been selectively depleted of CD4+CD25hiFoxp3+ regulatory T cells (Tregs; CD25hi Tregs) with potential to enhance graft-versus-tumor (GVT) immune responses in patients with myeloid relapse following a hematopoietic stem cell transplant (HSCT) from a matched donor. Following collection and ex-vivo depletion of CD25hi Tregs from PBMCs derived from the original donor, the CD25/Treg-depleted donor lymphocytes are infused into the patient. Upon administration, the CD25/Treg-depleted donor lymphocyte infusion (DLI) may enhance the proliferation of CD4+ and CD8+ effector T cells (Teffs) and potentially induce curative GVT immune responses in patients with myeloid relapse following HSCT.",
  "synonyms": [
    "allogeneic Treg-depleted donor lymphocytes",
    "CD25hi-depleted donor lymphocytes",
    "CD25/Treg-depleted donor lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-cd25-treg-depleted-donor-lymphocytes/"
}