allogeneic CD22-specific universal CAR-expressing T lymphocytes UCART22

{
  "id": "MLC-T-ONC-009849",
  "term": "allogeneic CD22-specific universal CAR-expressing T lymphocytes UCART22",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic, off-the-shelf (OTS), universal transcription activator-like effector nuclease (TALEN)-engineered T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human CD22 with potential immunomodulating and antineoplastic activities. Upon transfusion, allogeneic CD22-specific universal CAR-expressing T lymphocytes UCART22 express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces, resulting in lysis of CD22-expressing tumor cells. CD22, a cell surface glycoprotein, is expressed on mature B-cells and on most malignant B cells.",
  "synonyms": [
    "UCART22 cells",
    "allogenic engineered T cells expressing anti-CD22 CAR UCART22",
    "allogeneic gene-edited CAR T cells UCART22",
    "allogeneic TALEN gene-edited CAR T-Cells UCART22"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-cd22-specific-universal-car-expressing-t-lymphocytes-ucart22/"
}