Allogeneic anti-CD7 CAR T cells 4SCAR7U

{
  "id": "MLC-T-ONC-009824",
  "term": "Allogeneic anti-CD7 CAR T cells 4SCAR7U",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic, off-the-shelf (OTS), universal, gene-edited T lymphocytes expressing a fourth-generation chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD7 CAR T cells 4SCAR7U specifically target and kill CD7-expressing tumor cells. CD7 is a transmembrane glycoprotein expressed by T cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas.",
  "synonyms": [
    "4SCAR7U T cells",
    "allogeneic CD7-targeting universal CAR T cells 4SCAR7U",
    "allogeneic anti-CD7 CAR-T cells 4SCAR7U",
    "universal CD7-specific CAR gene-engineered T cells 4SCAR7U",
    "allogeneic anti-CD7 4SCAR-expressing T cells 4SCAR7U"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd7-car-t-cells-4scar7u/"
}