Allogeneic anti-CD7 CAR T cells

{
  "id": "MLC-T-ONC-009823",
  "term": "Allogeneic anti-CD7 CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of donor-derived T lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the allogeneic anti-CD7 CAR T cells specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas.",
  "synonyms": [
    "donor anti-CD7 CAR T cells",
    "donor-derived CD7 CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd7-car-t-cells/"
}