autologous anti-CD22 CAR-expressing T cells SCRI-CAR22v2

{
  "id": "MLC-T-ONC-011395",
  "term": "autologous anti-CD22 CAR-expressing T cells SCRI-CAR22v2",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous human T lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD22, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD22 CAR-expressing T cells SCRI-CAR22v2 express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces leading to lysis of CD22-expressing B cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B cells.",
  "synonyms": [
    "autologous anti-CD22 CAR T cells SCRI-CAR22v2",
    "autologous CD22-CAR-expressing T lymphocytes SCRI-CAR22v2"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd22-car-expressing-t-cells-scri-car22v2/"
}