Autologous anti-CD22 CAR-4-1BB-TCRz-transduced T lymphocytes CART22-65s

{
  "id": "MLC-T-ONC-011394",
  "term": "Autologous anti-CD22 CAR-4-1BB-TCRz-transduced T lymphocytes CART22-65s",
  "field": "Oncology and biomedicine",
  "definition": "Autologous human T lymphocytes transduced with a recombinant lentiviral vector encoding a chimeric antigen receptor (CAR) consisting of an anti-CD22 human single chain variable fragment (scFv) and linked to the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Upon reintroduction into the patient, the autologous anti-CD22 CAR-4-1BB-TCRz -transduced T lymphocytes CART22-65s express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces, resulting in lysis of CD22-expressing tumor cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B cells.",
  "synonyms": [
    "autologous anti-CD22 CAR T cells CART22-65s",
    "autologous CART22-65s-expressing T cells",
    "autologous CART22-65s cells",
    "autologous CART22-65s T cells",
    "autologous anti-CD22 scFv CAR 4-1BB-TCRz-expressing T lymphocytes CART22-65s"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd22-car-4-1bb-tcrz-transduced-t-lymphocytes-cart22-65s/"
}