Autologous anti-CD20 CAR-CD28-4-1BB-CD3zeta T lymphocytes MB-106

{
  "id": "MLC-T-ONC-011393",
  "term": "Autologous anti-CD20 CAR-CD28-4-1BB-CD3zeta T lymphocytes MB-106",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) cluster of differentiation 20 (CD20) and coupled to the co-stimulatory signaling domain CD28, the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD20CAR-CD28-4-1BB-CD3zeta T lymphocytes MB-106 specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated B-cell specific surface phosphoprotein that plays a role in the differentiation of B cells into plasma cells, is overexpressed in B-cell lineage malignancies and certain melanoma cell subpopulations.",
  "synonyms": [
    "autologous anti-CD20 CAR-T cells MB-106",
    "autologous anti-CD20CAR-CD28-4-1BB-CD3zeta-expressing T lymphocytes MB-106",
    "CD20-targeted autologous CAR-T cells MB-106"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd20-car-cd28-4-1bb-cd3zeta-t-lymphocytes-mb-106/"
}