Autologous anti-ICAM-1-CAR-CD28-4-1BB-CD3zeta-expressing T cells AIC100

{
  "id": "MLC-T-ONC-011459",
  "term": "Autologous anti-ICAM-1-CAR-CD28-4-1BB-CD3zeta-expressing T cells AIC100",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) containing the Inserted (I) domain variant of lymphocyte function-associated antigen-1 (LFA-1) which targets intercellular adhesion molecule-1 (ICAM-1 or CD54), and the co-stimulatory signaling domains of CD28, 4-1BB (CD137) and CD3zeta, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-ICAM-1-CAR-CD28-4-1BB-CD3zeta-expressing T cells AIC100 recognize and kill ICAM-1-expressing tumor cells. ICAM-1, normally expressed on leukocytes and endothelial cells, may be overexpressed in a variety of cancers. CAR-T cells AIC100 are also engineered to express somatostatin receptor subtype 2 (SSTR2), allowing the imaging of the CAR-T cells in patients.",
  "synonyms": [
    "autologous ICAM-1-targeted CAR-T cells AIC100",
    "autologous ICAM-1-targeted CAR T cells AIC100",
    "autologous ICAM-1-targeted CAR-T lymphocytes AIC100",
    "CAR-T cells AIC100"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-icam-1-car-cd28-4-1bb-cd3zeta-expressing-t-cells-aic100/"
}