bersanlimab

{
  "id": "MLC-T-ONC-011959",
  "term": "bersanlimab",
  "field": "Oncology and biomedicine",
  "definition": "A fully human IgG1 monoclonal antibody directed against intercellular adhesion molecule-1 (ICAM-1 or CD54), with potential antineoplastic activity. Bersanlimab selectively binds to the adhesion protein ICAM-1, which may result in antibody-dependent cellular cytotoxicity (ADCC), hyper-cross-linking-induced apoptosis, and a decrease in cellular proliferation of ICAM-1-expressing tumor cells. ICAM-1, normally expressed on leukocytes and endothelial cells, may be overexpressed in a variety of cancers.",
  "synonyms": [
    "anti-intercellular adhesion molecule-1 monoclonal antibody BI-505"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bersanlimab/"
}