anti-CD19-CAR-CD28/CD20-CAR-4-1BB-expressing autologous T lymphocytes Hu1928-Hu20BB

{
  "id": "MLC-T-ONC-010267",
  "term": "anti-CD19-CAR-CD28/CD20-CAR-4-1BB-expressing autologous T lymphocytes Hu1928-Hu20BB",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous human T lymphocytes that have been genetically modified to express the CAR construct Hu1928-Hu20BB that consists of two chimeric antigen receptor (CAR) constructs: one encoding a fully-human anti-CD19 CAR with a co-stimulatory domain of CD28, Hu19-CD828, and one encoding a human anti-CD20 CAR with a co-stimulatory domain of 4-1BB (CD137), Hu20BB, with potential immunostimulating and antineoplastic activities. Upon re-infusion, the anti-CD19-CAR-CD28/CD20-CAR-4-1BB-expressing autologous T lymphocytes Hu1928-Hu20BB recognize and kill CD19- and/or CD20-expressing tumor B cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19- and/or CD20-expressing tumor cells, thereby causing tumor cell lysis. Both the tumor-associated antigens (TAAs) CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies.",
  "synonyms": [
    "autologous CAR-19/CAR-20-T cells Hu1928-Hu20BB",
    "anti-CD19/CD20 CAR autologous T lymphocytes Hu1928-Hu20BB",
    "Hu1928-Hu20BB"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd19-car-cd28-cd20-car-4-1bb-expressing-autologous-t-lymphocytes-hu1928/"
}