allogeneic CD19/CD20-specific CAR-T cells P-CD19CD20-ALLO1

{
  "id": "MLC-T-ONC-009845",
  "term": "allogeneic CD19/CD20-specific CAR-T cells P-CD19CD20-ALLO1",
  "field": "Oncology and biomedicine",
  "definition": "An off-the-shelf (OTS) preparation of human allogeneic T lymphocytes containing primarily stem cell memory T cells (Tscm) that have been genetically modified to express two chimeric antigen receptors (CARs) targeting the tumor-associated antigens (TAAs) CD19 and CD20, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic CD19/CD20-specific CAR-T cells P-CD19CD20-ALLO1 specifically recognize and induce selective toxicity in CD19- and/or CD20-expressing tumor cells. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD19 and CD20 may prevent tumor cell antigen escape and relapse.",
  "synonyms": [
    "allogeneic anti-CD19/anti-CD20 CAR T cells P-CD19CD20-ALLO1",
    "allogeneic T stem cell memory CAR-T cells P-CD19CD20-ALLO1",
    "allogeneic Tscm CAR-T cells P-CD19CD20-ALLO1"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-cd19-cd20-specific-car-t-cells-p-cd19cd20-allo1/"
}