allogeneic CD19CAR-transfected cytokine-induced killer cells

{
  "id": "MLC-T-ONC-009844",
  "term": "allogeneic CD19CAR-transfected cytokine-induced killer cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic cytokine-induced killer (CIK) cells derived from peripheral blood mononuclear cells (PBMCs) transfected with the Sleeping Beauty (SB) transposon, CD19CAR (CARCIK-CD19), with potential immunomodulatory and antineoplastic activities. CIK cells are CD3- and CD56-positive, non-major histocompatibility complex (MHC)-restricted, natural killer (NK)-like T lymphocytes. Upon infusion following an allogeneic stem cell transplantation, the CARCIK-CD19 cells bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CIK cells may have enhanced cytotoxic activity compared to lymphokine-activated killer (LAK) cells. CD19 is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.",
  "synonyms": [
    "allogeneic CARCIK-CD19 cells",
    "allogeneic CARCIK-CD19",
    "transposon-manipulated allogeneic CARCIK-CD19 cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-cd19car-transfected-cytokine-induced-killer-cells/"
}