Autologous cytokine-induced killer cells/vaccinia virus DD-CDSR CRX100

{
  "id": "MLC-T-ONC-011592",
  "term": "Autologous cytokine-induced killer cells/vaccinia virus DD-CDSR CRX100",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous cytokine-induced killer (CIK) cells that have been generated ex vivo from killer cells treated with cytokines and infected with the oncolytic vaccinia virus DD-CDSR (vvDD-CDSR; double-deleted vaccinia virus plus CD/SMR), with potential immunomodulatory and antineoplastic activities. CIK cells are CD3- and CD56-positive, non-major histocompatibility complex (MHC)-restricted, natural killer (NK)-like T lymphocytes. Upon infusion of autologous CIK cells/vvDD-CDSR CRX100, the CIK cells protect the oncolytic virus vvDD-CDSR from immune attack and enhance the delivery of the oncolytic virus to tumor cells. The oncolytic virus vvDD-CDSR preferentially targets and infects tumor cells causing oncolysis. In turn, the lysed tumor cells release various tumor-associated antigens (TAAs), which induce an immune response against the tumor cells.",
  "synonyms": [
    "autologous CIK cells/vvDD-CDSR CRX100"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cytokine-induced-killer-cells-vaccinia-virus-dd-cdsr-crx100/"
}