allogeneic CD19CAR-CD28-CD3-zeta-expressing T lymphocytes

{
  "id": "MLC-T-ONC-009843",
  "term": "allogeneic CD19CAR-CD28-CD3-zeta-expressing T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic, donor-derived T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment), fused to the extracellular, transmembrane and intracellular signaling domains of the T-cell co-stimulatory receptor CD28 and the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta) (19-28z), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic CD19CAR-CD28-CD3-zeta-expressing T lymphocytes are directed to CD19-expressing tumor cells, which induces selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The CD28 co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. The inclusion of the CD28 signaling domain may increase proliferation of T cells and antitumor activity compared to the inclusion of the CD3-zeta chain alone.",
  "synonyms": [
    "allogeneic CD19-28z CAR T cells",
    "allogeneic 19-28z CAR T cells",
    "allogeneic 19-28z CAR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-cd19car-cd28-cd3-zeta-expressing-t-lymphocytes/"
}