allogeneic MUC1-C-specific CAR-T cells P-MUC1C-ALLO1

{
  "id": "MLC-T-ONC-009921",
  "term": "allogeneic MUC1-C-specific CAR-T cells P-MUC1C-ALLO1",
  "field": "Oncology and biomedicine",
  "definition": "An off-the-shelf (OTS) preparation of human allogeneic T lymphocytes containing primarily stem cell memory T cells (Tscm) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the C-terminal subunit of the tumor-associated antigen (TAA) mucin-1 (MUC1-C) and gene-edited to knockout both the T-cell receptor (TCR) and major histocompatibility complex (MHC) class I proteins, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic MUC1-C-specific CAR-T cells P-MUC1C-ALLO1 specifically recognize and induce selective toxicity in MUC1-C-expressing tumor cells. MUC1, a glycoprotein normally expressed on epithelial cells and overexpressed on the surface of a variety of cancer cells, plays a key role in tumor cell survival and proliferation. The proteolytic cleavage of MUC1 in the tumor microenvironment (TME) leads to the overexpression of MUC1-C in the TME.",
  "synonyms": [
    "allogeneic anti-MUC1-C CAR T cells P-MUC1C-ALLO1",
    "P-MUC1C-ALLO1 CAR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-muc1-c-specific-car-t-cells-p-muc1c-allo1/"
}