autologous Tn-MUC1-specific CAR T lymphocytes

{
  "id": "MLC-T-ONC-011778",
  "term": "autologous Tn-MUC1-specific CAR T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Tn glycoform of mucin-1 (Tn-MUC1; TnMUC1), with potential antineoplastic and immunostimulating activities. Upon re-introduction into the patient, the autologous Tn-MUC1-specific CAR T lymphocytes specifically recognize and induce selective toxicity in TnMUC1-expressing tumor cells. TnMUC1 is overexpressed in certain tumor types.",
  "synonyms": [
    "autologous CART-TnMUC1 cells",
    "anti-TnMUC1-CAR-expressing autologous T lymphocytes",
    "autologous TnMUC1-targeted genetically-modified CAR T cells",
    "autologous Tn-MUC1-specific CAR T cells",
    "autologous anti-TnMUC1-CAR-expressing T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-tn-muc1-specific-car-t-lymphocytes/"
}