autologous TNS9.3.55-transduced CD34-positive cells

{
  "id": "MLC-T-ONC-011779",
  "term": "autologous TNS9.3.55-transduced CD34-positive cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous, CD34-positive hematopoietic progenitor cells (HPCs) ex vivo transduced with TNS9.3.55, a lentiviral vector encoding the human beta-globin (hemoglobin-beta, HBB) gene, with potential to restore beta-globin expression and function. Autologous CD34-positive stem cells are isolated from the patient's own bone marrow, the deficient HBB gene is removed, and the cells are transduced with the lentiviral vector. Upon re-infusion of the TNS9.3.55-transduced CD34-positive cells back into the patient, these cells express beta-globin, thereby allowing the body to make normal hemoglobin and thus normal, healthy red blood cells. Beta-globin, the beta-chain of the most common form of hemoglobin, is encoded by the HBB gene; mutations in this gene prevent normal beta-globin production.",
  "synonyms": [
    "autologous TNS9.3.55-transduced CD34+ cells",
    "autologous CD34-positive cells transduced with TNS9.3.55"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-tns9-3-55-transduced-cd34-positive-cells/"
}