autologous tolerogenic proinsulin peptide-loaded dendritic cells PIpepTolDC

{
  "id": "MLC-T-ONC-011780",
  "term": "autologous tolerogenic proinsulin peptide-loaded dendritic cells PIpepTolDC",
  "field": "Oncology and biomedicine",
  "definition": "A vaccine composed of autologous tolerogenic dendritic cells (DCs) loaded with the beta cell protein proinsulin peptide (PIpep), C19-A3, with potential immunosuppressive and immune-regulating activities. Upon intradermal administration, the autologous tolerogenic PIpep-loaded DCs may induce proinsulin-specific regulatory T cells (Tregs). This may suppress the autoimmune destruction of the insulin-producing beta cells, thereby protecting the beta cells.",
  "synonyms": [
    "PIpepTolDC vaccine",
    "autologous tolerogenic PIpep-loaded dendritic cells PIpepTolDC",
    "proinsulin-loaded tolerogenic DCs PIpepTolDC",
    "autologous tolerogenic DC with proinsulin peptide PIpepTolDC",
    "tolerogenic DC vaccine PIpepTolDC"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-tolerogenic-proinsulin-peptide-loaded-dendritic-cells-pipeptoldc/"
}