Personalized peptides-loaded autologous dendritic cell vaccine

{
  "id": "MLC-T-ONC-015988",
  "term": "Personalized peptides-loaded autologous dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cell-based personalized cancer vaccine composed of autologous dendritic cells (DCs) loaded with the patient’s own tumor-specific peptides, with potential immunostimulatory and antineoplastic activities. Upon administration of the personalized peptides (PEP)-loaded autologous DC vaccine, the DCs activate natural killer cells (NKs) and stimulate a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient’s tumor cells expressing the PEPs, resulting in tumor cell lysis.",
  "synonyms": [
    "PEP-DC vaccine",
    "autologous dendritic cell vaccine loaded with personalized peptides",
    "PEP-loaded autologous DC vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/personalized-peptides-loaded-autologous-dendritic-cell-vaccine/"
}