personalized peptide cancer vaccine mBTCvax

{
  "id": "MLC-T-ONC-015987",
  "term": "personalized peptide cancer vaccine mBTCvax",
  "field": "Oncology and biomedicine",
  "definition": "A peptide-based, personalized cancer therapeutic vaccine consisting of patient-specific mutated tumor peptides, which are immunogenic and unique to the patient's tumor, combined with the immunostimulant polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose (poly-ICLC), with potential immunomodulating and antineoplastic activities. Upon administration, personalized peptide cancer vaccine mBTCvax stimulates the host immune system to mount a specific and potent cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the neoantigens, which results in tumor cell lysis. The adjuvant poly-ICLC is a ligand for toll-like receptor-3 (TLR3) and induces the release of cytokines which may help to boost the immune response against the selected neoantigens.",
  "synonyms": [
    "mBTCvax"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/personalized-peptide-cancer-vaccine-mbtcvax/"
}