personalized and adjusted neoantigen peptide vaccine PANDA-VAC

{
  "id": "MLC-T-ONC-015971",
  "term": "personalized and adjusted neoantigen peptide vaccine PANDA-VAC",
  "field": "Oncology and biomedicine",
  "definition": "A peptide-based, personalized cancer therapeutic vaccine consisting of up to 8 patient-specific tumor peptides, which are immunogenic and unique to the patient's tumor and identified through DNA and RNA sequencing of a patient's tumor cells, combined with the immunostimulant polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose (poly-ICLC), with potential immunomodulating and antineoplastic activities. Upon administration, personalized and adjusted neoantigen peptide vaccine PANDA-VAC stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the neoantigens, leading to tumor cell lysis. The adjuvant poly-ICLC is a ligand for toll-like receptor-3 (TLR3) and induces the release of cytokines which may help to boost the immune response against the selected neoantigens. The vaccine may be adjusted after initial therapy according to sequencing data.",
  "synonyms": [
    "PANDA-VAC",
    "personalized neoantigen peptide vaccine PANDA-VAC",
    "personalized neoantigen peptide-poly-ICLC vaccine PANDA-VAC"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/personalized-and-adjusted-neoantigen-peptide-vaccine-panda-vac/"
}