personalized cancer neoantigen vaccine GAd-PEV

{
  "id": "MLC-T-ONC-015972",
  "term": "personalized cancer neoantigen vaccine GAd-PEV",
  "field": "Oncology and biomedicine",
  "definition": "A personalized neoantigen priming vaccine comprised of a great ape (gorilla) adenoviral (GAd) vector encoding numerous patient-specific tumor neoantigens, which are identified based on patient-specific tumor mutations obtained from the individual’s tumor, with potential immunostimulatory and antineoplastic activities. The neoantigens are the same as the ones in the booster vaccine MVA-PEV. Upon administration of the priming vaccine personalized cancer neoantigen vaccine GAd-PEV, the neoantigens are expressed and presented to the immune system. This may induce CD8+ and CD4+ neoantigen-specific T-cell responses against the patient’s tumor cells expressing the neoantigens.",
  "synonyms": [
    "GAd-PEV",
    "nous-PEV priming vaccine GAd-PEV",
    "personalized vaccine GAd-PEV",
    "great ape adenoviral tumor-specific neoantigen priming vaccine GAd-PEV",
    "adenoviral tumor-specific neoantigen priming vaccine GAd-PEV",
    "prime vaccine GAd-PEV"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/personalized-cancer-neoantigen-vaccine-gad-pev/"
}