neoantigen DNA-based pancreatic cancer vaccine

{
  "id": "MLC-T-ONC-015469",
  "term": "neoantigen DNA-based pancreatic cancer vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A personalized, polyepitope DNA vaccine composed of a DNA plasmid encoding multiple, highly immunogenic tumor associated antigens (TAAs) that are specifically expressed by a patient's pancreatic cancer cells, including personalized epitopes of the TAA mesothelin, with potential immunostimulatory and antineoplastic activities. Upon intramuscular administration and electroporation of the neoantigen DNA-based pancreatic cancer vaccine, the expressed TAAs induce a specific cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing the neoantigens.",
  "synonyms": [
    "personalized neoantigen DNA pancreatic cancer vaccine",
    "neoantigen DNA pancreatic cancer vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/neoantigen-dna-based-pancreatic-cancer-vaccine/"
}