personalized neoantigen DNA vaccine GNOS-PVO2

{
  "id": "MLC-T-ONC-015978",
  "term": "personalized neoantigen DNA vaccine GNOS-PVO2",
  "field": "Oncology and biomedicine",
  "definition": "A personalized cancer vaccine consisting of patient-specific neoantigen-coding DNA plasmids, which are immunogenic and unique to the patient's tumor, with potential immunomodulating and antineoplastic activities. Upon intradermal delivery by electroporation of GNOS-PVO2, the patient-specific neoantigens are translated in cells and elicit a specific and potent cytotoxic T-lymphocyte (CTL) response against tumor cells expressing these neoantigens, resulting in tumor cell lysis. Each patient-specific formulation may contain multiple DNA plasmids, and each plasmid may contain multiple neoantigen DNA sequences, allowing the delivery of multiple neoantigen DNA sequences simultaneously.",
  "synonyms": [
    "neoantigen vaccine GNOS-PVO2"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/personalized-neoantigen-dna-vaccine-gnos-pvo2/"
}