Neoantigen-based glioblastoma vaccine

{
  "id": "MLC-T-ONC-015475",
  "term": "Neoantigen-based glioblastoma vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A peptide-based, personalized glioblastoma cancer vaccine consisting of patient-specific glioblastoma-derived immunogenic mutated epitopes (neoantigens), with potential immunomodulating and antineoplastic activities. Vaccination with the neoantigen-based glioblastoma vaccine stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the neoantigens, which results in tumor cell lysis. Neoantigens are tumor-specific antigens derived from mutated proteins that are present only in a specific tumor.",
  "synonyms": [
    "personalized neoantigen glioblastoma vaccine",
    "NeoVax (TM) glioblastoma vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/neoantigen-based-glioblastoma-vaccine/"
}