personalized neoantigen vaccine NECVAX NEO1

{
  "id": "MLC-T-ONC-015984",
  "term": "personalized neoantigen vaccine NECVAX NEO1",
  "field": "Oncology and biomedicine",
  "definition": "A personalized, oral Ty21a-based neoantigen vaccine consisting of eukaryotic expression plasmid encoding patient-specific tumor neoantigens that are immunogenic and unique to the patient's tumor, with potential immunomodulating and antineoplastic activities. Upon oral administration of personalized neoantigen vaccine NECVAX NEO1, the patient-specific neoantigens elicit a specific and potent cytotoxic T-lymphocyte (CTL) response against tumor cells expressing these neoantigens. Ty21a is a live-attenuated Salmonella typhi strain oral typhoid vaccine that is modified and used to deliver the neoantigens-encoding plasmids to the gut-associated lymphoid tissue.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/personalized-neoantigen-vaccine-necvax-neo1/"
}